It has been reported that pulmonarysurfactants or their components could facilitate the uptake of small interfering RNA (siRNA) into the lung epithelial cells.
1
Secretion of pulmonarysurfactant in the alveoli of the lungs is essential to maintain lung function.
2
Mixtures of PxB and pulmonarysurfactant show antimicrobial effects in neonatal rabbits and prevent systemic spreading of E. coli.
3
In neonatal pneumonia, the surface activity of pulmonarysurfactant is impaired and microorganisms may invade by passing the air-liquid interface.
4
Recent studies have demonstrated that pulmonarysurfactant protein (SP)-A plays a potential role in modifying inflammation and immune function.
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However, it is vital that corticosteroids delivered via the lungs not interfere with surface activity of the pulmonarysurfactant lining layer.
Uso de lung surfactant em inglês
1
Therefore, the gas transfer characteristics of lungsurfactant film are of fundamental physiological interest.
2
The experimental results suggest that lungsurfactant plays a role in oxygen transfer in the pulmonary system.
3
In addition to their effects on alveolar surface tension, some components of lungsurfactant also have immunological functions.
4
The source of FA in the lung is believed to be phosphatidylcholine, the major component of lungsurfactant.
5
The mechanism by which lungsurfactant achieves very low near-zero surface tensions, well below its equilibrium value, is not fully understood.
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We found recently that the hydrophobic lungsurfactant protein SP-C specifically binds to the lipid A region of lipopolysaccharide (LPS).
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This research studies the biophysical surface activity of synthetic phospholipids combined in vitro with purified lungsurfactant apoprotein, having an Mr of 6000.
8
The squeeze-out process follows a nucleation-growth model and only occurs within a narrow surface pressure range around the equilibrium spreading pressure of lungsurfactant.
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The current study provides evidence that sequence-random copolymers can mimic the in vitro surface-active behavior of lungsurfactant proteins in a mixed lipid film.
10
Previously, LPCAT1 has been suggested to be critical for the production of lungsurfactant phospholipids and biosynthesis of platelet-activating factor in noninflammatory remodeling pathway.
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The Michigan team modeled an unhealthy lung by using liquid that was missing lungsurfactant, which normally reduces surface tension in the bronchial tubes.
12
Biophysical studies of the CLSE replacement surfactant containing only SAP 6-14 and native phospholipids demonstrated full surface activity compared to natural lungsurfactant.
13
This study emphasizes the crucial functional activity of SP-B in lungsurfactants.